How ShennonBio discovers T-cell engagers

How TCELERATOR screens 10 million single-cell interactions in one run

One T cell, one target cell, one droplet. How ordered loading, droplet incubation and functional sorting rank thousands of designs in a single experiment.

Why function beats binding affinity in T-cell engager discovery

Binders can be designed in days, but proving they make a T cell kill takes months. Why leads are selected on killing from day 1.

Why a trispecific T-cell engager for small cell lung cancer

Tarlatamab validated T-cell engagers in SCLC and 30+ programs crowd one target. Why SBT-121 engages 2 tumor antigens in 1 molecule.

Why intracellular targets need TCR-based T-cell engagers

Antibodies only reach the cell surface. TCR-based T-cell engagers read peptide-HLA and open the intracellular proteome to an off-the-shelf drug.