Next-Gen Superior Drugs Require Targeted Insights

The development of safer and more effective drugs requires granular understanding of the disease-relevant cell populations. However, due to the heterogeneity of the disease states and the diversity of the immune system, the disease relevant cells are like needles in a haystack. To study these cells in a population, we need a sensitive platform at the million-cell throughput to identify and comprehensively characterize them. However, no existing technologies can achieve this with acceptable speed and cost.

What We Do

We combine ultrafast screening with advanced AI models to greatly speed up drug development. We’ve developed a proprietary platform -- TCELERATORTM that functionally profiles individual cell-cell interactions at ultrahigh speed followed by multidimensional computational analysis. We can process 10s of millions of events in one go, functionally characterize each one of them and uncover new insights within rare populations. We also curated a proprietary multidimensional large dataset of tumor and normal samples. The combination of TCELERATORTM and the dataset enabled us to build advanced custom AI models that halve the time and cost of development across target discovery, drug design, and safety screening. This allows us to identify and validate new targets and develop effective drugs that are safe at lower cost.  

Careers

We love working with great people and solving critical problems. Come join us.

Current openings

Scientist / Senior Scientist in Immunology - T cell Engagers

San Francisco, CA

Full-time

Senior / Machine Learning Research Scientist

San Francisco, CA

Full Time

Research Associate

San Francisco, CA

Full Time

Join Our Talent Pool

San Francisco, CA

Full Time

Scientist / Senior Scientist in Immunology - TCR-T

San Francisco, CA

Full Time

CSO / VP of R&D

San Francisco, CA

Full Time

Leadership and Scientific Advisors

Li Sun, PhD

CEO & Founder

Former VC at Foundation Capital and Bessemer Venture Partners, PhD in Applied Physics from Harvard University

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David Weitz, PhD

Scientific Advisor

Expert in single cell platforms, Professor of Physics and Applied Physics

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Joseph Fraietta, PhD

Scientific Advisor

T cell expert, Director of the Solid Tumor Immunotherapy Lab

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Benjamin Greenbaum, PhD

Scientific Advisor

Expert in neoantigen prediction, Computational Oncologist

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Niroshana Anandasabapathy, MD/PhD

Scientific Advisor

Associate Professor of Dermatology in Microbiology and Immunology

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Jonathan Esensten, MD/PhD

Scientific Advisor

Physician scientist and expert in regulatory T cells for autoimmune diseases

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Paul Thomas, PhD

Scientific Advisor

Professor and Program Head, Immunology and Vaccine Development Program

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Ian Chen, PhD

Staff Engineer

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Dan Griffith, PhD

ML Computational Biologist

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Paul Shafer, PhD

Scientist

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Lauren Hunter

Biomedical Engineer

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Naomi Ptak

Operations Manager

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Kaitao Li, PhD

Associate Director

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Sonali Kanaya

Senior Research Associate

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Bianca Pierrat

Research Associate

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Michael Malone, PhD

Senior Scientist

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Kelsy Cotto, PhD

Senior Computational Biologist

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Tek Hyung Lee

Senior Scientist

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Jon DiRusso, PhD

Scientist

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Michael Kalos, PhD

Scientific Advisor

Former CSO in Cancer Immunobiology at Eli Lilly, former VP in Immuno-oncology and Oncology Cell Therapies at J&J

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Kristen Hege

Advisor

Former SVP of Early Clinical Development in Oncology at Bristol Myers Squibb

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Girish Aakalu

Advisor

Former VP and Global Head of Innovation at Ipsen, former Head of Strategy and Innovation at Pfizer

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OUR ADVANTAGES

STEP 1

Functional Dataset and Broad Spectrum AI Engine to Discover Novel Targets

We developed the most comprehensive AI engine that integrates multiple dimensions of data from a large set of tumor and normal samples. It enables us to discover therapeutically relevant, novel targets for 'undruggable' diseases, providing a therapeutic path for patients with limited or no treatment options.

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Functional Ultrafast Screening to Find Best Therapeutic Binders

TCELERATORTM  platform probes 10s of millions of functional interactions dynamically, which allows us to screen for the best therapeutic binders efficiently.

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Left arrow

AI-Driven Deep Molecular Scanning to Predict Potential Adverse Reactivity for Clinical Safety

Our AI model searches wide and deep into molecular details of normal human tissues to look for potential cross reactivity with the drug candidate. This approach has enabled us to successfully predict 100% of previously reported toxicity events, providing a powerful safeguard for our drug design process.

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