The Challenges

Why we need single cell profiling.

Immune cells are very diverse. How to functionally identify and sort out antigen-specific T/B cells from the 100 billion T/B cells in the body with a diversity of a billion has been a known bottleneck. It’s equivalent to searching for a needle in a haystack. Over the past decade, many efforts have been made to figure out how to profile such a diverse population and especially pick out the very rare ones that are effective targets for cancer immunotherapy. However, few technologies developed can functionally profile the immune cells and even fewer can do this at the single-cell level, and almost no one can do this at such an ultrahigh throughput that enables target identification and selection.

Ultrahigh Throughput Functional Pairing

Our Solution

At ShennonBio, we’ve developed a proprietary single cell platform that functionally profiles individual immune cells at ultrahigh throughput to resolve this bottleneck. We can process millions of cells within an hour, functionally characterize each one of them and pull out the rare targets within a day. This allows us to capitalize on the diversity of the immune repertoire and identify immune cells that can target almost any disease. The potential of the platform is limitless. Our first focus is to profile and identify T cells and T cell receptors to develop more effective immunotherapies for solid tumors.

Careers

We love working with great people and solving critical problems. Come join us.

Current openings

Research Associate

San Francisco, CA

Full Time

Computational Biologist

San Francisco, CA

Full Time

Senior Microfluidics Engineer

San Francisco, CA

Full Time

Scientist / Senior Scientist in Immunology

San Francisco, CA

Full Time

Director / VP of R&D

San Francisco, CA

Full Time

Leadership and Scientific Advisors

Li Sun, PhD

CEO & Founder

Former VC at Foundation Capital and Bessemer Venture Partners, PhD in Applied Physics from Harvard University

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Kaveh Milaninia, PhD

CTO & Head of Platform

Serial entrepreneur in life science tools, PhD in Materials Science from Massachusetts Institute of Technology

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David Weitz, PhD

Scientific Advisor

Expert in single cell platforms, Professor of Physics and Applied Physics

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Joseph Fraietta, PhD

Scientific Advisor

T cell therapy expert, Director of the Solid Tumor Immunotherapy Lab

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Benjamin Greenbaum, PhD

Scientific Advisor

Expert in neoantigen prediction, Computational Oncologist

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Niroshana Anandasabapathy, MD/PhD

Scientific Advisor

Melanoma expert, Associate Professor of Dermatology in Microbiology and Immunology

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Jonathan Esensten, MD/PhD

Scientific Advisor

Expert in cell therapy development and manufacturing, Medical Director of the GMP facility

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Paul Thomas, PhD

Scientific Advisor

T cell expert, Faculty in the Immunology Department

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Ian Chen, PhD

Staff Platform Engineer

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Nicole Lee

Platform Engineer

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Naomi Ptak

Operations Manager

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Kaitao Li, PhD

Principal Scientist

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Solenn Matuska

Research Associate

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Sandra Nielsen, PhD

Senior Scientist

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Michael Malone, PhD

Scientist

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The Process

STEP 1

T cell profiling

We use our platform to profile millions of T cells against our pool of antigens, and select out the antigen specific T cells corresponding to each antigen.

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STEP 2

TCR Discovery and Validation

We sequence the selected T cells to uncover the TCRs and map them to the antigens. We then validate the TCRs by testing their specificity and functionality rigorously both in vitro and in vivo.

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STEP 3

Engineered Cell Therapy

We work with our clinical partners and pharma partners to run clinical trials and to develop the therapies to treat patients.

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