Precision Immunotherapies for Solid Tumors Built on Functional Biology at the Single-Cell Level


We develop precision immunotherapies for solid tumors through an integrated technology platform spanning target discovery, ultra-high-throughput microfluidics-driven functional screening, computational binder design and predictive safety assessment.
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We develop both antibody-based and TCR-based T-cell engagers designed to address surface and intracellular cancer targets. Our initial oncology pipeline includes programs in small cell lung cancer, ovarian cancer and hepatocellular carcinoma.

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Where conventional discovery tests binders sequentially over months, our TCELERATORTM platform profiles more than 10 million single-cell interactions at once, identifying functional leads in a single experiment, with a hit rate of >80%. We further combine this platform with computational biology and translational immunology into a unified engine to develop more selective and safer molecules, starting with next-generation T-cell engagers.

This biology-driven approach is supported by proprietary human tumor datasets built through an expanding network of academic and clinical collaborators across 15 institutions, and 8,000 square feet of laboratory and office space in San Francisco near UCSF Mission Bay.

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Centered around people

We believe that people are the key that drives scientific and organizational successes. We are dedicated to building an environment where everyone thrives. We have a culture of collaboration, ownership, and authenticity. We are proud to have built an interdisciplinary team that embodies this culture.   

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Careers

We love working with great people and solving critical problems. Come join us.

Current openings

Scientist / Senior Scientist in Immunology - T-cell Engagers

San Francisco, CA

Full-time

Join Our Talent Pool

San Francisco, CA

Full-time

CSO / VP of R&D

San Francisco, CA

Full-time

Leadership and Scientific Advisors

Portrait of Li Sun, PhD

Li Sun, PhD

Founder, President and CTO

Former VC Partner at Foundation Capital, Inventor of ShennonBio's core technology

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Portrait of David Weitz, PhD

David Weitz, PhD

Scientific Advisor

Expert in single-cell platforms, Professor of Physics and Applied Physics

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Portrait of Joseph Fraietta, PhD

Joseph Fraietta, PhD

Scientific Advisor

T-cell expert, Director of the Solid Tumor Immunotherapy Lab

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Portrait of Niroshana Anandasabapathy, MD, PhD

Niroshana Anandasabapathy, MD/PhD

Scientific Advisor

Associate Professor of Dermatology in Microbiology and Immunology

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Portrait of Paul Thomas, PhD

Paul Thomas, PhD

Scientific Advisor

Professor and Program Head, Immunology and Vaccine Development Program

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Portrait of Dan Griffith, PhD

Dan Griffith, PhD

Computational Protein Scientist

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Portrait of Paul Shafer, PhD

Paul Shafer, PhD

Scientist in Immunology

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Portrait of Lauren Hunter

Lauren Hunter

Platform Engineer

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Portrait of Kaitao Li, PhD

Kaitao Li, PhD

Director of R&D

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Portrait of Sonali Kanaya

Sonali Kanaya

Senior Research Associate

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Portrait of Kelsy Cotto, PhD

Kelsy Cotto, PhD

Senior Computational Biologist

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Portrait of Tek Hyung Lee, PhD

Tek Hyung Lee, PhD

Senior Protein Scientist

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Portrait of Jon DiRusso, PhD

Jon DiRusso, PhD

Molecular Scientist

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Portrait of Michael Kalos, PhD

Michael Kalos, PhD

Scientific Advisor

Former CSO in Cancer Immunobiology at Eli Lilly, former VP in Immuno-oncology and Oncology Cell Therapies at J&J

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Portrait of Kristen Hege, MD

Kristen Hege, MD

Advisor

Former SVP of Early Clinical Development in Oncology at Bristol Myers Squibb

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Portrait of Girish Aakalu, PhD

Girish Aakalu, PhD

Advisor

CEO of Phenomic AI; former VP and Global Head of External Innovation at Ipsen, former Head of External R&D Innovation at Pfizer

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Portrait of Rick Austin, PhD

Rick Austin, PhD

Scientific Advisor

T-cell engager discovery expert, former VP of Research at Harpoon Therapeutics

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Portrait of Eugene Zhukovsky, PhD

Eugene Zhukovsky, PhD

Scientific Advisor

Antibody Engineering Expert, former Chief Scientific Officer at Affimed and Biomunex

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Portrait of Cyril Konto, MD

Cyril Konto, MD

Chief Executive Officer

Biotech Veteran

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Portrait of Chad Putnam

Chad Putnam

Fractional Chief Financial Officer

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Portrait of Gaurav Vij

Gaurav Vij

Head of Business Development (Fractional)

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Portrait of Priyanka Mukherjee

Priyanka Mukherjee

Senior Research Associate

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Latest News

Drug Discovery Online logo
Oct 6, 2026

Finding The Therapeutic Window: Using Single-Cell Biology To Build More Selective T-Cell Engagers

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BioCentury logo
Sep 22, 2026

ShennonBio: Mining rare T cells for solid tumor therapies

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Bioxconomy logo
Sep 15, 2026

Shennon lands $12m and new CEO to drive immunotherapy pipeline forward

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BiotechTV logo
Sep 14, 2026

Shennon Biotechnologies announces a new CEO, Cyril Konto, and a $12M raise for its T-cell engager programs

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FirstWord Pharma logo
Sep 14, 2026

Shennon adds $12M, unveils trio of T-cell engager programmes

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Business Wire logo
Sep 14, 2026

Shennon Biotechnologies Raises $12M in Financing, Appoints Cyril Konto, M.D., as Chief Executive Officer and Unveils Precision Immunotherapy Pipeline

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BioSpace logo
Sep 14, 2026

Shennon Biotechnologies Raises $12M in Financing, Appoints Cyril Konto, M.D., as Chief Executive Officer and Unveils Precision Immunotherapy Pipeline

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Pulse 2.0 logo
Sep 14, 2026

Shennon Biotechnologies Raises $12 Million, Names Cyril Konto As CEO, And Unveils Precision Immunotherapy Pipeline

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SITC Women in Cancer Immunotherapy Network logo
Sep 10, 2026

ShennonBio Founder Dr. Li Sun serves as a panelist at SITC's Women in Cancer Immunotherapy Leadership Institute

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San Francisco Business Times logo
Mar 15, 2023

How a onetime VC came back to science to focus on finding better targets faster against cancer

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Endpoints News logo
Mar 13, 2023

Immunotherapy biotech unstealths with $13M

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Business Wire logo
Mar 13, 2023

Shennon Biotechnologies Raises $13M Seed Financing to Accelerate Immunotherapy Target Discovery with Proprietary Single-Cell Functional Screening Platform

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